In step with globalization, developing students’ intercultural competence has become an important mission in Japanese higher education. This mission is particularly evident in the context of English-medium instruction. This paper discusses three major challenges in promoting intercultural learning in universities: (1) defining intercultural competence and identifying key dimensions of the competence, (2) developing reliable and valid measures assessing intercultural competence, and (3) teaching intercultural competence and documenting instructional outcomes.