If there are no basic flaws in the design of the study, rewrite the manuscript carefully according to the reviewers' suggestions, show it to colleagues for feedback, and refine it further. Then try sending it to another journal. If there are basic design flaws, then treat it as a learning experience and conduct further research, making sure to address the design flaws that were identified so that the new research is publishable. All authors, even the most famous ones, have been rejected at one time or another. It's part of the professional development process.
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